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Thorne   Methyl-Guard Plus® - 90 Capsules

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60 Reviews

"Great product"  Read all reviews

Item Number: TR1285
Serving Size: 3 Capsules Servings per Container: 30
Price per Serving:  $1.73 Price per Unit*: $0.58 per Capsule
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
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Supports heart‚ blood vessel‚ brain‚ and bone health by enhancing healthy methylation

Methyl-Guard Plus provides 5-MTHF (active folate) and the active‚ tissue-ready forms of vitamins B2‚ B6‚ and B12 to support healthy methylation for cardiovascular‚ cognitive‚ and bone health.

Methylation is key to keeping homocysteine levels in check‚ as well as for facilitating multiple biochemical processes involving neurotransmitter synthesis‚ detoxification‚ cardiovascular health‚ eye health‚ muscle health‚ bone health‚ and redox balance. Maintaining a desirable level of homocysteine in the blood has joined healthy cholesterol and triglyceride levels as leading biomarkers for the maintenance of good cardiovascular health. Preventing an undesirable homocysteine level is also associated with the maintenance of bone‚ female reproductive‚ cognitive‚ and neurological health. Methyl-Guard Plus supports methylation and promotes healthy homocysteine levels with betaine (trimethylglycine)‚ 5-MTHF (the active form of folate)‚ riboflavin 5'-phosphate (the active form of vitamin B2)‚ pyridoxal 5'-phosphate (the active form of vitamin B6)‚ and methylcobalamin (an active form of vitamin B12).

Methylation – the addition of a methyl group (one carbon atom attached to three hydrogen atoms) to another molecule – is an essential and vital biochemical process that is involved in multiple biochemical pathways involving neurotransmitter synthesis‚ detoxification‚ cardiovascular health‚ eye health‚ muscle health‚ bone health‚ and redox balance. A number of specific nutrients are necessary for methylation processes to occur normally. Maintaining a normal homocysteine level in the blood is important for good cognitive health. A deficiency in the cofactors that metabolize homocysteine is commonly observed in the elderly‚ which results in increasing homocysteine levels with advancing age. These elevated levels of homocysteine associated with aging‚ as well as low levels of folic acid and vitamins B6 and B12‚ can result in the decreased methylation of numerous substances‚ including DNA and proteins‚ which can diminish the integrity of vascular structures and neurons. Therefore‚ providing nutritional cofactors for homocysteine metabolism provides support for a healthy brain.

A number of biochemical imbalances that can raise homocysteine levels can be addressed by supplementing with the appropriate nutrient cofactors. These include folic acid (as L-5-methyltetrahydrofolate)‚ vitamin B12 (as methylcobalamin)‚ and betaine (trimethylglycine)‚ which promote the recycling of homocysteine to the amino acid methionine. In addition‚ the breakdown of homocysteine into beneficial amino acids cysteine and taurine can be facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6). Studies have shown these nutrients help maintain normal homocysteine levels in the blood.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # SF789
  • UPC # 693749789017
Official Website:

Serving Size: Three Capsules
Servings Per Container: 30

Three Capsules Contain / %DV

Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg / 6‚923%
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg / 2‚647%
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid‚ Glucosamine Salt) 5 mg DFE / 1‚250%
Vitamin B12 (as Methylcobalamin) 3 mg / 125‚000%
Betaine Anhydrous (Trimethylglycine) 1.8 g / *

*Daily Value (DV) not established.

Other Ingredients: Hypromellose (derived from cellulose) capsule‚ Calcium Citrate‚ Calcium Laurate.

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid‚ Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A.

Gluten Free.

Take 1-3 capsules daily or as recommended by your health practioner.

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

If pregnant‚ consult your health professional before using this product.

5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy‚ as it can interfere with methotrexate's anti-neoplastic activity; however‚ 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Use only if bottle is sealed. Store tightly sealed in a cool‚ dry place.

  • Egg Free
  • Gluten Free
  • High Fructose Corn Syrup Free
  • Nut Free
  • Peanut Free

Ratings and Reviews

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  • 4.9
5 60
  • 60 Reviews
    • Verified Buyer

      Energy booster

      from Greenville on 6/06/2022
      I definitely can tell when I forget to take my methyl-guard plus, as my energy and mood are much lower. I only take one capsule a day and that dose gives the boost I need, since having COVID.


      It boosts my energy and mood.


      It seems plenty pricey.
      review-checkI would recommend this item to a friend.
    • B12 B Good

      from Decatur GA on 3/09/2022
      This contains the right amount per capsule that I need for everyday use.


      Strength, Capsules


      Quantity (I need 120 ct or more)
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Convenient High Quality Folate + B

      from Arizona on 4/12/2021
      I use this supplement to help with absorption of methylfolate. The folate and B vitamin blend is convenient and effective.
      review-checkI would recommend this item to a friend.
    • A little too high dose for me, but works

      from Connecticut on 2/15/2021
      I need to take this every other day as daily doses make me speedy and interfere with my sleep. Forgetting to take it for a month sent me into a deep depression that almost landed me, incorrectly, on anti-depressants AND resulted in a Crohn's flare. Once I realized I had stopped taking it, and resumed, I was instantly back to my old in just hours after. I never expected this supplement to have such a strong affect. I do wish they offered a lower dosage or a pill form that could be cut. Every body is different and needs are not the same.


      It works. The combination of active ingredients is key.


      Too high a dose does not allow for customization.
      review-checkI would recommend this item to a friend.
      1 of 1 people found the following review helpful.
    • Very Good Supplement

      from Lebanon IL on 11/05/2020
      My husband takes this. Helps to keep his homocysteine levels in check for his cardiovascular health



      review-checkI would recommend this item to a friend.
    • RNP recommended this. So glad she did!

      from the West on 10/10/2020
      My B12 level was very low. It runs in the family...The RNP told me about this and said she has good results. The bottle says to take 2 a day but I only take one. My labs came back in normal range! I couldn't believe it. I do feel more energetic and if I skip a day, I can tell as I'm very sluggish and tired. The only downside is bright neon yellow urine. I know that's the body getting rid of excess B vitamins. I do think they are pricey but I haven't found anything at the stores that have the same effect. And I've tried many B complex vitamins and stress vitamins!! This is my personal review and I was NOT paid to say any of this.


      My labs are finally in normal range and I feel better as far as energy


      Bright yellow urine and price
      review-checkI would recommend this item to a friend.
    • Methylguard

      from Louisiana on 9/05/2020
      I was tested by a doctor I do not Store iron in my body have Anemia this works great an I’m not tired


      Easy to take an works


      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Methyl-Guard Plus

      from Troy MI on 6/29/2020
      Great product
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Great quality product

      from Oregon on 5/13/2020
      This was recommended by my daughter's neuropsychologist to help with anxiety, stress and focus. Excellent results in balancing gene function.



      review-checkI would recommend this item to a friend.
    • Better than other offerings

      from Earth on 4/14/2020
      There have been some times when I questioned the product’s efficacy, but after sharing my concerns with others I believe Thorne offers the best - albeit imperfect - supplement of this type.


      I believe it is providing some benefit, however it is hard to know conclusively because I have introduced multiple health-lifestyle improvements myself.


      Thorne is true to its word about continuous and consistent product purity. However, my experience with attempting to have a meaningful answer to my product inquiries has been less than fruitful.
      review-checkI would recommend this item to a friend.
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Customer Questions and Answers

1-2 of 2

  • Question:
    How do u increase daily pill from 1 pill to 3 pills?
    Beverly Mcclister on 9/02/2014 Answer:
    • Hello Beverly, thank you for contacting PureFormulas. To get a better recommendation on how to take Methyl-Guard Plus, we suggest contacting your practitioner. 
      Raisa on 9/02/2014
  • Question:
    Would taking Methyl-guard AND Lipotrepin AND Resveratrol AND Choleast at one time each day be too much???????
    Carol Geroux on 8/30/2014 Answer:
    • Hello Carol, thank you for contacting PureFormulas. We suggest contacting your health care practitioner for a better recommendation. 
      Raisa on 9/02/2014

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