Thorne   5-MTHF 1 mg - 60 Capsules

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Item Number: TR1229
Serving Size: 1 Capsule Servings per Container: 60
Price per Serving:  $0.37 Price per Unit*: $0.37 per Capsule
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
126 In Stock.

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Active folate for mood‚ heart health‚ fetal development‚ and nerve support*

5-MTHF is an active‚ tissue-ready form of folate. It's an essential B vitamin that supports methylation. Many individuals don't get sufficient 5-MTHF because they have intestinal or liver dysfunction or because of their genetic makeup.*

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate)‚ the active form of folic acid‚ because they have intestinal or liver dysfunction‚ or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF. A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects‚ which is why the Centers for Disease Control recommends folic acid supplementation for all women of childbearing age. Since 5-MTHF also contributes to the production of serotonin‚ melatonin‚ dopamine‚ epinephrine‚ and norepinephrine‚ supplementation supports healthy mood.

Note: 1 mg of 5-MTHF is recommended for fetal support during pregnancy; the 15 mg option is recommended only when directed by a health-care practitioner.

It is important for a woman of childbearing age to get enough folic acid – not just those women who are planning to become pregnant. Because half of pregnancies are unplanned‚ any woman who could become pregnant should get enough folic acid every day. Folic acid intake is especially important before conception and during early pregnancy‚ since its biggest need is during the first trimester – when a woman might not even know she is pregnant. Supplementation with the active form of folic acid – 5-MTHF (L-5 Methyltetrahydrofolate)– is always preferable.

Acting with vitamin B12‚ 5-MTHF functions as a methyl-group donor‚ thereby facilitating the conversion of the amino acid homocysteine to methionine. An elevated homocysteine level is a risk factor for a number of undesirable health conditions. Methyl-group donation is vital to many biochemical conversion processes‚ including the synthesis of serotonin‚ melatonin‚ and DNA.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # B129
  • UPC # 693749129011
Official Website:

Serving Size: One Capsule
Servings Per Container: 60

One Capsule Contains: / %DV

Folate (1 mg as L-5-Methyltetrahydrofolate†) 1.7 mg DFE / 425%

Daily Value (DV)

Other Ingredients: Microcrystalline Cellulose‚ Hypromellose (derived from cellulose) capsule‚ Leucine‚ Silicon Dioxide.

Gluten Free.

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A.

Take 1 capsule one to three times daily or as recommended by your health-care practitioner.

TAMPER EVIDENT: Use only if bottle is sealed. Store tightly sealed in a cool‚ dry place.

If pregnant‚ consult your health-care practitioner before using this product.

  • Egg Free
  • Gluten Free
  • High Fructose Corn Syrup Free
  • Nut Free
  • Peanut Free

Ratings and Reviews

Write a Review
  • 4.8
5 59
  • 59 Reviews
    • Great Product

      from New York on 10/12/2022
      I have been taking for a year. No problems with the product.
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Anti Inflammatory health

      from Washington on 9/27/2022
      Easy to swallow, small in size and when tested my inflammation levels have improved based on blood test results performed by my Naturopath.


      Small size and results


      review-checkI would recommend this item to a friend.
    • Verified Buyer


      from USA on 9/04/2022




      review-checkI would recommend this item to a friend.
    • Verified Buyer

      I have used this product for years. My

      from LINCOLN CA on 3/23/2022
      One of the best quality 5-MTHF products on the market.
      review-checkI would recommend this item to a friend.
    • Great if you have intestinal dysfunction

      from New Jersey on 12/19/2021
      Taking this product because my digestive system is compromised, and I want to ensure I get the active form of folic acid. I've been taking Thorne products for several years, and am happy with their quality.


      Active form of folic acid delivered in small capsule


      review-checkI would recommend this item to a friend.
    • Verified Buyer


      from NY on 7/08/2021
      Being low on folic acid, my primary prescribed a generic folic acid. My chiropractor recommended this one as being a much safer and more beneficial option


      reccomended from someone I trust


      review-checkI would recommend this item to a friend.
    • Verified Buyer

      good product

      from Norwalk CT on 6/09/2021
      Been taking for years for MTHFR mutation- I think it helps plus a methyl b12 supplement


      doesnt seem to give me any side effects and i cna supplement with a B12 of my choice


      nothing would be nice if it were more affordable
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Great product

      from Wisconsin on 6/26/2020
      This is a great form of B the form that everyone can absorb rather than going through the system without doing any good!
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Have used this product for several years

      from LEWISTON NY on 3/06/2020
      I use this for my MTHFR issues. Works great!
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Great Product

      from Franklin TN on 10/02/2019
      This product helped me


      great value and fast shipping


      review-checkI would recommend this item to a friend.
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Additionally, PureFormulas is unable to directly recommend products in relation to specific health conditions. Please contact your trusted healthcare practitioner for direct product recommendations.

If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008

If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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